Sabine van Schie
I'm intrigued by the question of how lipids reach their respective membranes, and in the lab I'm trying to address this by mapping the genetic and functional wiring of lipid transport at membrane contact sites. Outside of the lab I enjoy dancing and exploring the great outdoors. My favorite science quote is by Robert Sapolsky: "Science is not meant to cure us of mystery, but to reinvent and reinvigorate it".
Exploiting homologous recombination increases SATAY efficiency for loss- and gain-of-function screening Agnès H. Michel, Sabine van Schie, Andreas Mosbach, Gabriel Scalliet, Benoît KornmannbioRxiv 866483; doi: https://doi.org/10.1101/866483 The analysis of large-scale transposon mutant libraries is becoming a method of choice for functional genomics in bacteria and fungi. We previously established SAturated Transposon Analysis in Yeast (SATAY)...
An Active Site Rearrangement Within the Tetrahymena Group I Ribozyme Releases Nonproductive Interactions and Allows Formation of Catalytic Interactions RN Sengupta et al. RNA 22 (1), 32-48. Jan 2016. PMID 26567314. Biological catalysis hinges on the precise structural integrity of an active site that binds and transforms its substrates and meeting this requirement presents a unique …
Differential Assembly of Catalytic Interactions Within the Conserved Active Sites of Two Ribozymes SN van Schie et al. PLoS One 11 (8), e0160457. 2016. PMID 27501145. Molecular recognition is central to biology and a critical aspect of RNA function. Yet structured RNAs typically lack the preorganization needed for strong binding and pr …
A Transcriptional Circuit Filters Oscillating Circadian Hormonal Inputs to Regulate Fat Cell Differentiation Z Bahrami-Nejad et al. Cell Metab 27 (4), 854-868.e8. 2018. PMID 29617644. Glucocorticoid and other adipogenic hormones are secreted in mammals in circadian oscillations. Loss of this circadian oscillation pattern correlates with obesity in huma …
An Active Site Rearrangement Within the Tetrahymena Group I Ribozyme Releases Nonproductive Interactions and Allows Formation of Catalytic Interactions RN Sengupta et al. RNA 22 (1), 32-48. Jan 2016. PMID 26567314. Biological catalysis hinges on the precise structural integrity of an active site that binds and transforms its substrates and meeting this requirement presents a unique …
Differential Assembly of Catalytic Interactions Within the Conserved Active Sites of Two Ribozymes SN van Schie et al. PLoS One 11 (8), e0160457. 2016. PMID 27501145. Molecular recognition is central to biology and a critical aspect of RNA function. Yet structured RNAs typically lack the preorganization needed for strong binding and pr …
A Transcriptional Circuit Filters Oscillating Circadian Hormonal Inputs to Regulate Fat Cell Differentiation Z Bahrami-Nejad et al. Cell Metab 27 (4), 854-868.e8. 2018. PMID 29617644. Glucocorticoid and other adipogenic hormones are secreted in mammals in circadian oscillations. Loss of this circadian oscillation pattern correlates with obesity in huma …