Christian Covill-Cooke
Christian is a Cell Biologist with a broad interest in organelle homeostasis. After finishing his PhD at UCL studying mitochondrial and peroxisomal dynamics, he now investigates the transfer of lipids across organelle-contact sites using yeast genetics and mass spectrometry. ORCID: https://orcid.org/0000-0002-4479-8734
1. PMID: 29311115 Miro Proteins Coordinate Microtubule- And Actin-Dependent Mitochondrial Transport and Distribution G López-Doménech et al. EMBO J 37 (3), 321-336. 2018. PMID 29311115. In the current model of mitochondrial trafficking, Miro1 and Miro2 Rho-GTPases regulate mitochondrial transport along microtubules by linking mitochondria to kinesin and …
2. PMID: 28711655 Ubiquitination at the Mitochondria in Neuronal Health and Disease C Covill-Cooke et al. Neurochem Int 117, 55-64. Jul 2018. PMID 28711655. - Review The preservation of mitochondrial function is of particular importance in neurons given the high energy requirements of action potential propagation and synaptic transmis …
3. PMID: 31562315 Miro Clusters Regulate ER-mitochondria Contact Sites and Link Cristae Organization to the Mitochondrial Transport Machinery S Modi et al. Nat Commun 10 (1), 4399. 2019. PMID 31562315. Mitochondrial Rho (Miro) GTPases localize to the outer mitochondrial membrane and are essential machinery for the regulated trafficking of mitochondria to defined subcell …
4. PMID: 26740581 Expanding the CRISPR Imaging Toolset With Staphylococcus Aureus Cas9 for Simultaneous Imaging of Multiple Genomic Loci B Chen et al. Nucleic Acids Res 44 (8), e75. 2016. PMID 26740581. In order to elucidate the functional organization of the genome, it is vital to directly visualize the interactions between genomic elements in living cells. For this pur …
5. PMID: 31894645 Peroxisomal Fission Is Modulated by the Mitochondrial Rho-GTPases, Miro1 and Miro2 C Covill-Cooke et al. EMBO Rep e49865. 2020. PMID 31894645. Peroxisomes are essential for a number of cellular functions, including reactive oxygen species metabolism, fatty acid β-oxidation and lipid synthesis. To ensure optimal …
2. PMID: 28711655 Ubiquitination at the Mitochondria in Neuronal Health and Disease C Covill-Cooke et al. Neurochem Int 117, 55-64. Jul 2018. PMID 28711655. - Review The preservation of mitochondrial function is of particular importance in neurons given the high energy requirements of action potential propagation and synaptic transmis …
3. PMID: 31562315 Miro Clusters Regulate ER-mitochondria Contact Sites and Link Cristae Organization to the Mitochondrial Transport Machinery S Modi et al. Nat Commun 10 (1), 4399. 2019. PMID 31562315. Mitochondrial Rho (Miro) GTPases localize to the outer mitochondrial membrane and are essential machinery for the regulated trafficking of mitochondria to defined subcell …
4. PMID: 26740581 Expanding the CRISPR Imaging Toolset With Staphylococcus Aureus Cas9 for Simultaneous Imaging of Multiple Genomic Loci B Chen et al. Nucleic Acids Res 44 (8), e75. 2016. PMID 26740581. In order to elucidate the functional organization of the genome, it is vital to directly visualize the interactions between genomic elements in living cells. For this pur …
5. PMID: 31894645 Peroxisomal Fission Is Modulated by the Mitochondrial Rho-GTPases, Miro1 and Miro2 C Covill-Cooke et al. EMBO Rep e49865. 2020. PMID 31894645. Peroxisomes are essential for a number of cellular functions, including reactive oxygen species metabolism, fatty acid β-oxidation and lipid synthesis. To ensure optimal …