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Exploiting homologous recombination increases SATAY efficiency for loss- and gain-of-function screening Agnès H. Michel, Sabine van Schie, Andreas Mosbach, Gabriel Scalliet, Benoît KornmannbioRxiv 866483; doi: https://doi.org/10.1101/866483 The analysis of large-scale transposon mutant libraries is becoming a method of choice for functional genomics in bacteria and fungi. We previously established SAturated Transposon Analysis in Yeast (SATAY)...
Functional Mapping of Yeast Genomes by Saturated Transposition AH Michel et al. Elife 6. 2017. PMID 28481201. Yeast is a powerful model for systems genetics. We present a versatile, time- and labor-efficient method to functionally explore the Saccharomyces cerevisiae genom …
Structure-function Insights Into Direct Lipid Transfer Between Membranes by Mmm1-Mdm12 of ERMES S Kawano et al. J Cell Biol 217 (3), 959-974. 2018. PMID 29279306. The endoplasmic reticulum (ER)-mitochondrial encounter structure (ERMES) physically links the membranes of the ER and mitochondria in yeast. Although the ER and mitochond …
Cytotoxicity of 1-deoxysphingolipid Unraveled by Genome-Wide Genetic Screens and Lipidomics in Saccharomyces cerevisiae AG Haribowo et al. Mol Biol Cell 30 (22), 2814-2826. 2019. PMID 31509475. Hereditary sensory and autonomic neuropathy (HSAN) types IA and IC (IA/C) are caused by elevated levels of an atypical class of lipid named 1-deoxysphingolipid (DoxSL). H …
The ERMES Complex and ER-mitochondria Connections AH Michel et al. Biochem Soc Trans 40 (2), 445-50. Apr 2012. PMID 22435828. - Review Cellular organelles need to communicate in order to co-ordinate homoeostasis of the compartmentalized eukaryotic cell. Such communication involves the formation of membra …
Organization and Function of Membrane Contact Sites SC Helle et al. Biochim Biophys Acta 1833 (11), 2526-41. Nov 2013. PMID 23380708. - Review Membrane-bound organelles are a wonderful evolutionary acquisition of the eukaryotic cell, allowing the segregation of sometimes incompatible biochemical reactions into s …
Spontaneous rDNA Copy Number Variation Modulates Sir2 Levels and Epigenetic Gene Silencing AH Michel et al. Genes Dev 19 (10), 1199-210. 2005. PMID 15905408. We show that in budding yeast large rDNA deletions arise frequently and cause an increase in telomeric and mating-type gene silencing proportional to repeat loss. Paradox …
A Condensin-Like Dosage Compensation Complex Acts at a Distance to Control Expression Throughout the Genome J Jans et al. Genes Dev 23 (5), 602-18. 2009. PMID 19270160. In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of one sex to equalize levels of X-gene products between males (1X) and females (2X). He …
Functional Mapping of Yeast Genomes by Saturated Transposition AH Michel et al. Elife 6. 2017. PMID 28481201. Yeast is a powerful model for systems genetics. We present a versatile, time- and labor-efficient method to functionally explore the Saccharomyces cerevisiae genom …
Structure-function Insights Into Direct Lipid Transfer Between Membranes by Mmm1-Mdm12 of ERMES S Kawano et al. J Cell Biol 217 (3), 959-974. 2018. PMID 29279306. The endoplasmic reticulum (ER)-mitochondrial encounter structure (ERMES) physically links the membranes of the ER and mitochondria in yeast. Although the ER and mitochond …
Cytotoxicity of 1-deoxysphingolipid Unraveled by Genome-Wide Genetic Screens and Lipidomics in Saccharomyces cerevisiae AG Haribowo et al. Mol Biol Cell 30 (22), 2814-2826. 2019. PMID 31509475. Hereditary sensory and autonomic neuropathy (HSAN) types IA and IC (IA/C) are caused by elevated levels of an atypical class of lipid named 1-deoxysphingolipid (DoxSL). H …
The ERMES Complex and ER-mitochondria Connections AH Michel et al. Biochem Soc Trans 40 (2), 445-50. Apr 2012. PMID 22435828. - Review Cellular organelles need to communicate in order to co-ordinate homoeostasis of the compartmentalized eukaryotic cell. Such communication involves the formation of membra …
Organization and Function of Membrane Contact Sites SC Helle et al. Biochim Biophys Acta 1833 (11), 2526-41. Nov 2013. PMID 23380708. - Review Membrane-bound organelles are a wonderful evolutionary acquisition of the eukaryotic cell, allowing the segregation of sometimes incompatible biochemical reactions into s …
Spontaneous rDNA Copy Number Variation Modulates Sir2 Levels and Epigenetic Gene Silencing AH Michel et al. Genes Dev 19 (10), 1199-210. 2005. PMID 15905408. We show that in budding yeast large rDNA deletions arise frequently and cause an increase in telomeric and mating-type gene silencing proportional to repeat loss. Paradox …
A Condensin-Like Dosage Compensation Complex Acts at a Distance to Control Expression Throughout the Genome J Jans et al. Genes Dev 23 (5), 602-18. 2009. PMID 19270160. In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of one sex to equalize levels of X-gene products between males (1X) and females (2X). He …
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